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Confused about MTHFR, B12, and what a genetic mutation could mean for your health?


Around 40%+ of people around the world have some form of MTHFR genetic mutation, and yet most of them don’t know it.


MTHFR (methylenetetrahydrofolatereductase) is the enzyme produced by the MTHFR gene. It’s required for metabolizing folate and breaking down the amino acid homocysteine. Vitamin B12 also plays a major role as a cofactor in the methylation process of folate and the conversion of homocysteine to methionine.


However, mutations of the MTHFR gene can significantly affect your ability to turn vitamin B12 and folate into forms the body can utilize. This can lead to low levels of B12, which has serious consequences for your health and wellbeing



Vitamin B12 is involved in almost every bodily function. It helps make DNA and red blood cells, and plays a key role in the brain and nervous system. B12 is required alongside folate for healthy methylation, and the production of S-adenosylmethionine (SAMe).


B12 and folate are both required for the conversion of homocysteine to methionine. Deficiency of either nutrient may lead to increased homocysteine levels, a major risk factor in cardiovascular disease and many other chronic conditions such as diabetes.


Without B12, your body simply cannot function as it should. Because this nutrient is so intimately involved in red blood cell production and nervous system maintenance, deficiency is a major cause of fatigue, neurological disorders, anxiety, nerve pain, and depressionamong others.


Dose: as indicated on bottle. 

Recommendation - Test your B12 first and see what your levels are. Book in for a pathology analysis appointment if you need help. 

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